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Sermorelin, CJC-1295 and Ipamorelin instead stimulate the pituitary to release the bodys own growth hormone in a more natural pulsatile pattern

10.3390/ijerph120910806 200 WangX.XiaT.Addo NtimS.JiZ.LinS.MengH.et al (2011)

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The interplay between the somatotropic axis and sleep regulation has been extensively documented in both preclinical and clinical studies, demonstrating the integral role of growth hormonereleasing hormone (GHRH), somatostatin, GH itself, insulin-like growth factor-I (IGF-I), synthetic GH secretagogues, and ghrelin in modulating sleep architecture ( In normal individuals, sleep-onset GH secretion appears to be primarily regulated by GHRH stimulation during a period of relative somatostatin withdrawal